By Michel Goldberg
This booklet presents an in depth replace on our wisdom of dental pulp and regenerative techniques to treatment. it truly is divided into 3 components. The pulp parts are first defined, protecting pulp cells, extracellular matrix, vascularization and innervation in addition to pulp improvement and getting older. the second one half is dedicated to pulp pathology and contains descriptions of the diversities among reactionary and reparative dentin, the genetic changes resulting in dentinogenesis imperfecta and dentin dysplasia, the pulp response to dental fabrics, antagonistic affects of bisphenol A and the results of fluorosis, dioxin and different poisonous brokers. the ultimate a part of the publication specializes in pulp fix and regeneration. It comprises descriptions of varied in vitro and in vivo (animal) experimental ways, definition of the pulp stem cells with precise specialize in the stem telephone niches, dialogue of the regeneration of a residing pulp and knowledge on new ideas that set off pulp mineralization.
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Additional resources for The Dental Pulp: Biology, Pathology, and Regenerative Therapies
Lacerda-Pinheiro S, Dimitrova-Nakov S, Harichane Y, Souyri M, Petit-Cocault L, Legrès L, Marchadier A, Baudry A, Ribes S, Goldberg M, Kellermann O, Poliard A. Concomitant multipotent and unipotent dental pulp progenitors and their respective contribution to mineralised tissue formation. Eur Cell Mater. 2012;23:371–86. 12. Stanislawski L, Carreau J-P, Pouchelet M, Chen ZHJ, Goldberg M. In vitro culture of human dental pulp cells: some aspects of cells emerging early from the explant. Clin Oral Investig.
The pulpo-dentinal complex revisited. J Dent. 1995;23:15–20. 2. Baume LJ. Biology of pulp and dentin. In: Monographs in oral science. Basel: S. Karger AG; 1980. 3. Kenmotsu M, Matsuzaka K, Kokubu E, Azuma T, Inoue T. Analysis of side population cells derived from dental pulp tissue. Into Endod J. 2010;43:1132–42. 4. Couve E, Schmachtenberg O. Autophagic activity and aging in human odontoblasts. J Dent Res. 2011;90: 523–8. 5. Goldberg M, Smith A. Cells and extracellular matrices of dentin and pulp.
6 Immune Defense Mechanisms of the Dental Pulp  Antigen-presenting cells (APC) are, namely, dendritic cells, macrophages, B lymphocytes, and endothelial cells. They express class II MHC molecules. Using an antihuman leukocyte antigen (HLA)-DR monoclonal antibody, immunopositive cells appear with a spindle-like or a dendritic profile. They are densely distributed throughout the dental pulp. They exhibit various sizes of vesicles, enclosing electron-lucent or electron-dense contents, multivesicular bodies, and characteristic tubulovesicular structures as well.