By C. Gopinath, D. Prentice, D.J. Lewis
Our objective in generating a color atlas of toxicological guidance itemize the investigations to be performed pathology used to be to offer a listing of histopathologi in the course of the process the research they usually commonly comprise: cal lesions which we had encountered through the years in scientific observations and behavior; nutrients consumption and physique quite a few laboratory animal species uncovered to an unlimited weight measurements; serum biochemistry; haema variety of prescription drugs, agrochemicals and commercial tology; ECG and ophthalmology. on the finish of a learn, chemical compounds. whereas we think a color atlas is the appropriate complete macroscopic and microscopic examinations of how to percentage our reviews with others, it fast organ weight analyses including tissues are essen turned transparent to us that for the atlas to be significant tial. by means of a ways the better a part of the cloth utilized in this the linked textual content needs to be finished and include e-book is from toxicity reviews carried out lately plentiful literature references. and played in compliance with the nice Laboratory The atlas is meant for either the trainee and the perform criteria of governmental regulatory our bodies in skilled toxicological pathologist operating with lab Europe, Japan and North the US. oratory animals within the pharmaceutical, agrochemical or Toxicity stories are as a rule conducted in rats, chemical environment.
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Extra info for Atlas of Experimental Toxicological Pathology
The affected area reveals a minimal inflammatory reaction. 9 Centrilobular area of necrosis and degeneration showing depletion of glycogen staining in the liver of a calf given a single oral dose of chloroform. 10 Centrilobular area of necrosis showing histochemical loss of liver specific enzyme in the liver of a horse treated with a single dose of chloroform. 11 Centrilobular area of necrosis showing increased activity of non-specific alkaline phosphatase in the liver of a horse treated with a single oral dose of chloroform.
The macrophages contain brown pigment presumably a metabolic product of the test compound. 67 Squamous metaplasia of an alveolar wall from a rat. 66) a small nest of squamous cells with superficial keratinization has developed on an alveolar wall. Some alveolar walls show epithelialization. In this study the epithelialization developed in the absence of initial diffuse alveolar damage. 68 Alveolar lipoproteinosis induced in a rat by inhalation of quartz. The alveoli are filled with an amorphous, weakly eosinophilic material with increased numbers of macrophages and focal thickening of the alveolar walls.
71 Alveolar macrophages from a rat with induced phospholipidosis. These phagocytic cells are distended with tightly packed, round inclusions. 1 jlm section. 72 Phospholipidosis induced in a rat lung. The alveoli and macrophages contain numerous electron-dense multilamellar bodies which are believed to be produced by the Type II pneumonocytes. Electron micrograph 39 THE RESPIRATORY SYSTEM rats following butylated hydroxytoluene-induced damage, in which inhibition of epithelial cell proliferation (and re-epithelialization) by high oxygen concentration results in fibrosis 41 .